welcome to Grey Matter

Grey Matter is an organisation focused on independent research and development,
standardization and production of high purity peptides, modified proteins,
resins and nanotubes for both organic synthesis and peptide synthesis to clients across the globe.

SERVICES & MODIFICATION

Grey Matter is an organisation focused on independent research and development,
standardization and production of high purity peptides, modified proteins,
resins and nanotubes for both organic synthesis and peptide synthesis to clients across the globe.

IMAGINATION | INNOVATION | FOUNDATION

Grey Matter is an organisation focused on independent research and development,
standardization and production of high purity peptides, modified proteins,
resins and nanotubes for both organic synthesis and peptide synthesis to clients across the globe.



Welcome to GMR Foundation Pvt Ltd.

Grey Matter Organisation

Grey Matter is an organisation focused on independent research and development, standardization and production of high purity peptides, modified proteins, resins and nanotubes for both organic synthesis and peptide synthesis to clients across the globe. The company is devoted to innovation and focused on providing project based research services and caters to the needs of pharmaceutical, biotech, chemical and agri sectors. Our extensive expertise and broad range of products and services helps our customers in their research all the way to the next generation of therapeutic drugs. At Grey Matter, we devise and develop innovative approaches that clearly focus on and directly address various risks in R&D. Our recent successful work includes production of low cost peptides through a innovative process. We strive to be your partner by delivering high quality products at the right price, which helps you through your peptide development process.

The company also takes up contract research to various multinational biopharma companies across the globe. And also has been delivering custom made peptides regularly to keep a place in the market. With a strategic business model Grey Matter ensures the right price for its services with adherence to international CGMP and ISO standards.

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ABOUT US

Grey Matter Research Foundation Private Limited (GMRF)is an independent research organisation focused on research and development, standardization and production of high purity carbon nano tubes, carbon nano sponge, nano foams, peptides, modified proteins and resins for both organic synthesis and peptide synthesis. Grey Matter was formed by researchers and academicians who are committed to innovation and delivering it efficiently. Our research strategy is to help our clients in R&D, which can help in commercialization of peptide therapeutics.

ABOUT GREY MATTER

“Our years of expertise in this field, and patents on manufacture of peptides by SPPS makes us a reliable partner in the field on peptide research” – Dr. K.PSubashchandran, Vice Chairman & Ex- Managing Director.
Grey Matter Research Foundation Private Limited (GMRF)is an independent research organisation focused on research and development, standardization and production of high purity carbon nano tubes, carbon nano sponge, nano foams, peptides, modified proteins and resins for both organic synthesis and peptide synthesis. Grey Matter was formed by researchers and academicians who are committed to innovation and delivering it efficiently. Our research strategy is to help our clients in R&D, which can help in commercialization of peptide therapeutics.
We have been keenly working with government organizations who have been funding us with our research and also been delivering custom made peptides to several universities and companies for research. We would continue to serve the biotechnology community by our affordable innovation, by which we can touch the lives of million living beings.

OUR MISSION :
To help R&D labs and companies in India and abroad working in pharmaceutical, polymer and nanotechnology based research with value added products and services.
OUR VISION :
To be a world-class organization focusing on R&D and Innovation to create a better tomorrow.
OUR PEOPLE :
Our Strength is our people. Grey Matter team has a perfect blend of qualified and experienced scientists and focused management working in complete synergy, backed by an advisory board of international reputation.
The members of the Group include renowned academicians, researchers and scientists in this field. They have held various reputable positions in India and abroad. They are also pioneers in the field of Polymer chemistry, Peptide chemistry, Synthetic Organic chemistry and Nanoscience.
The Grey Matter Group has the experience, facilities, staff and excellent management team to support your project throughout the highly regulated development and production process.

Peptide Technologies : LPPS & SPPS
Grey Matter Group provides several strategies for peptide synthesis to support projects of any size. Our production chemists and analytical development team have extensive experience with a large variety of peptides and synthetic strategies at all scales, and we can help optimize your project by developing the most robust, economical manufacturing processes.

We excel in all major peptide fields:

Liquid (solution) Based Peptide Synthesis(LPPS) :
LPPS is the technology of choice for many peptides, particularly shorter peptides or structures that prevent attachment to a resin matrix. LPPS is especially appropriate for shorter sequences that need to be manufactured at large scale.
Solid Phase Peptide Synthesis (SPPS) :
SPPS is well suited to manufacturing peptide APIs, particularly longer, more complex sequences. Our team has extensive experience in both Fmoc and t-Boc strategies, and we will work with you to decide on the best approach, depending on your specific sequence and your final requirements. We have the capacity to manufacture large quantities of peptides with complex sequences using SPPS.

Our commitment to quality is reflected throughout the manufacturing process. Starting materials of the highest quality are purchased from qualified vendors and carefully evaluated prior to use. The final product is subjected to a series of analytical tests. You are assured of consistent, reliable and timely supplies of high purity pharmaceutical-grade peptides. Every product manufactured undergoes a set of analytical tests. Some of the common tests include

1.Color/Appearance
2.Water Content by Karl Fischer
3.Identity and Purity by HPLC
4.Amino Acid Analysis
5.Molecular Weight
6.Peptide Content by Nitrogen Analysis amino acid analysis
7.Acetate Content by HPLC
8.Trifluoroacetic Acid (TFA) Content by amino acid analysis
9.Related Substances (Impurities) by HPLC
10.Residual Solvents by GC-MS
11.Sequencing by MS-MS
12.Heavy Metals by ICP-MS
13.Specific Optical Rotation and circular dichroism
14.Solubility

Our standard Specifications Include :
1.Appearance
2.Solubility
3.Identity (via mass spectral analysis, amino acid analysisand HPLC)
4.Peptide purity (HPLC)
5.Related substances (HPLC)
6.Assay (peptide content)
7.Counterion content
8.Moisture content
9.Trifluoroacetic acid
10.Residual organic solvents
11.Other API-specific parameters

We can add or make changes to specifications based on your specific requests.




PRODUCT & SERVICES

Combining the extensive experience in custom peptide synthesis and analytical chemistry, our scientists use a variety of proprietary chemical processes. We intend to provide our customers worldwide with the high quality peptides in a short turnaround time and at a competitive price.

CUSTOM SYNTHESIS

The company was formed to cater for the increasing requirement of contract peptide synthesis. Our main focus is in the development, manufacture and supply of high purity, high value peptide and peptidomimetic compounds through the use of advance technologies.

Quantities for research up to pilot scale can be provided at predefined purity levels, and can include modifications such as cyclization, biotinylation, phosphorylation, as well as labeling with fluorescent dyes or radioactive isotopes
Development :
Analytical characterization of any lead peptide designated for manufacture is started as soon as the campaign starts. The primary issue is not achieving a specified purity, but in meeting impurity specifications. If impurities are not uncovered early in a project (and eliminated via improvements in purification or synthesis), the consequences can be substantial down the line.
With our proprietary technologies, a niche network of scientists and facilities, Grey Matter has the capabilities and capacity to deliver your peptide products in an efficient and timely manner. We provide all regulatory documentation required for commercial production and usage

Once a proprietary manufacturing process has been validated and approvedthe production of the peptide becomes one of contract manufacturing. Depending on the scale of the manufacturing process and the annual requirements for the peptide, the process may be regulated specifically to suit the peptide API (Active Pharmaceutical Ingredient).
Quantity :
Grey Matter specializes in developing small and large-scale production processes for proprietary peptides. Whether you require gram or multi-kilogram quantities, we can support your custom project at every step, even with the most complex peptides.

Non peptidic Molecules:
1.From the simplest to the most complex structures
2.From several grams to several hundreds of grams
3.Manufacturing at kilogram scale
Price and delivery time will depend on the specific chemical structure and bibliographic study of known processes. The client will be charged only on a successful syntheses.
Please Contact Us to discuss your specific custom synthesis or design of synthons that may be of interest. All information will be strictly confidential.

PRODUCT& SERVICES

Combining the extensive experience in custom peptide synthesis and analytical chemistry, our scientists use a variety of proprietary chemical processes. We intend to provide our customers worldwide with the high quality peptides in a short turnaround time and at a competitive price.

Peptide Technologies : LPPS & SPPS
1.Biotinylated peptides
2.Phosphorylated peptides
3.Cyclic peptides
4.Glycopeptides
5.Cysteine containing peptides
6.Modified peptides
    N-terminus
    C-terminus
    Unusual amino acids
* Other Modifications
1.Intermolecular disulphide bridges
2.Lipids (farnesyl, stearoyl etc)
3.N-C cyclisation
4.PEGylation
5.Side-Chain Linked (-Asp, -Glu, -Lys)

*Labelled peptides

Our product range includes the following peptides :
1.ACTH (Corticotropin)
2.Angiotensin
3.Buserelin
4.Calcitonin
5.Deslorelin
6.Felypressin
7.Gonadorelin Acetate
8.Gonadorelin, HCl
9.Goserelin
10.Leuprolide
11.Octreotide
12.Oxytocin
13.Somatostatin
14.Triptorelin
15.Vasopressin, 8-L-Arginine(Arg-Vasopressin, Argipressin)

Resins for SPPS & SPOS:
1.Resins for Peptide Acids by Fmoc/ Boc Strategy
2.Resins for Peptide Amides by Fmoc/ BocStraegy
3.Very Acid Labile Resins for Peptide Derivatives by Fmoc-Strategy
4.Scavenger Resins
5.Miscellaneous Resins


Special amino acids and derivatives, organic building blocks and turn mimics are useful tools for your peptide design. We have accumulated great experience in expected properties of organic building blocks. Over 600 unusual amino acids and organic building blocks in stock featuring beta-amino acids, gamma-amino acids, aminobenzoic acids, polyethylene glycol spacers, statines, diamines and more, that illustrate our particular know-how in special peptide and peptidomimetic synthesis.
Protected Amino Acids & Derivatives :

L-Amino Acids

Alanine
Arginine
Aspartic Acid
Cysteine
Glutamic Acid
Glutamine
Glycine
Homocysteine
Hydroxyproline (trans and cis)
Leucine
Lysine
Methionine
Ornithine
Phenylalanine
Proline
Serine
Thyronine
Tryptophan
Tyrosine
Valine
PseudoprolineDipeptides Organic Building Blocks Miscellaneous

Our services include :
Synthesis of peptidomimetics.
Modification of proteins:

1.PEGylation 2.Biotinylation, etc.

Synthesis of small organic compounds
Multi step synthesis
Contract research
Felypressin
Gonadorelin Acetate
Library design and synthesis
Process development and optimisation
Resins for organic synthesis
Resins for peptide synthesis
Micro porous and macro porous resins
Chromatographic resins
High Purity Carbon Nanotubes and related new product development initiatives.
Vasopressin, 8-L-Arginine(Arg-Vasopressin, Argipressin) We are an active partner in your project's success.

Our service package includes:
Process development
Preparation and characterization of an in-house reference standards
In-house impurity reference standards
Analytical methods development and characterization
Analytical methods validation
Full stability testing according to ICH guidelines (over 4 years at storage temperature)
Process validation
All batch documentation and any support documentation required, including a CMC/IND package and a US or European DMF as needed
Support with regulatory agencies

Some of Modifications we do :
BSA/KLH Conjugation.
Coumarin
Cy3 and Cy5
Dabcyl
Dansyl
Cyclic peptide through disulfide bridges
Cyclic peptides
EDANS
Farnesyl
FITC
MAPS (Multiple Antigenic Peptide System)
MCA (7-Methoxycoumarin-4-yl) Acetyl
Palmitoyl
PEGylation
Phosphorylation
PNA (para-Nitroaniline)
Rhodamine 110
Rhodamine B
Ser (octanoic acid)
Stearic acid modification
TAMRA (Tetramethylrhodamine)
Texas Red
Sulfated peptide [Tyr(SO3)] and Many more

Nanotubes :
As Nanotechnology transcends every other field from medicine to electronics and energy to environment, we understand the growing needs of one of the most sought after material.
Carbon Nanotubes
Single-walled
Double-walled

how it works

CONTACT US

Grey Matter is committed to being your long-term partner, with the knowledge you can depend on and the expertise you can trust. Use the Quote Form below to get a confidential quote.

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